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Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice

Inada, M.; Yamashita, J.; Ogawa, M.

Research Communications in Molecular Pathology and Pharmacology 97(2): 229-232

1997

ISSN/ISBN: 1078-0297
PMID: 9344234
Document Number: 474621
We examined the in vivo effects of ONO-5046 cntdot Na, a specific neutrophil elastase (NE) inhibitor, on the growth of 2 non-small cell lung cancer cell lines, EBC-1 and PC-3, transplanted into severe combined immunodeficiency (scid) mice. The daily intraperitoneal injection of ONO-5046-Na (50 mg/kg/day) completely suppressed the tumor growth in EBC-1, a human squamous carcinoma cell line which produces immunoreactive NE. By contrast, in PC-3, a human adenocarcinoma cell line which is unable to produce immunoreactive NE, the ONO-5046-Na treatment caused delayed growth of the tumor. These findings suggest that ONO-5046-Na may have a clinical role in preventing the growth of human non-small cell lung cancer.

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