Inhibition of HIV-1 replication by targeting the Rev protein
Nakaya, T.; Iwai, S.; Fujinaga, K.; Otsuka, E.; Ikuta, K.
Leukemia 11(Suppl 3): 134-137
1997
ISSN/ISBN: 0887-6924 PMID: 9209321 Document Number: 474350
Human immunodeficiency virus type 1 (HIV-1) encodes two regulatory proteins, Tat and Rev. The Rev protein facilitates the transport of unspliced and singly-spliced RNA to the cytoplasm in infected host cells by binding to target RNA (Rev response element: RRE). A variety of approaches targeting Rev function, including gene therapy, have been developed that inhibit HIV-1 replication in cells cultured in vitro. This minireview summarizes the recent developments as well as our application of the Rev-binding element-based decoy approach using RNA-DNA chimera oligonucleotide modeling.