The effects of Tripterygium wilfordii polyglycosidium on neuromuscular junctions of adult toad
Lü, G.; Zhou, L.; Xu, J.
Hua Xi Yi Ke Da Xue Xue Bao 28(2): 145-148
1997
ISSN/ISBN: 0257-7712 PMID: 10683922 Document Number: 473881
The effects of tripterygium wilfordii polyglycosidium (TWP) on the transmission at the neuromuscular junctions (NMJ) of sciatic nerve-sartorius muscle preparations of 20 adult toads (Bufo bufo gargarizans) in vitro were studied by means of intracellular microelectrode recording of endplate potentials (EPP). The results revealed that TWP could cause changes of EPP amplitude so as to influence the transmission at NMJ, and the effects apparently depended on the concentration of the drug. A proper concentration of TWP could produce a significant increase in EPP amplitude and therefore facilitate the transmission at the NMJ.