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The effect of multi-glycosides of Tripterygium wilfordii Hook f. (GTW) on the survival time of cardiac allografts in rats

Yang, X.; Xu, L.; Ren, H.; Li, Z.; Sun, C.; Zhang, Z.

Chinese Medical Sciences Journal 7(4): 232-234

1992

ISSN/ISBN: 1001-9294
PMID: 1307500
Document Number: 403207
Heterotopic heart transplantation was carried out in rats and the influence of multi-glycosides of Tripterygium wilfordii Hook f. (GTW) and a subtherapeutic dose of cyclosporine A (CsA) on the mean survival time (MST) of the cardiac allografts was investigated. The results showed that the MSTs of cardiac allografts in both the GTW and CsA-treated groups were significantly prolonged (P lt 0.01 vs control). The rate of allograft rejection in the drug-treated groups was much lower than that in the control group.

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