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Prolonged survival of heart allografts in rats treated with antisera to beta2-microglobulin

Bjorck, L.; Konrad, P.; Husberg, B.; Berggard, I.

Transplantation 23(4): 383-386

1977

ISSN/ISBN: 0041-1337
PMID: 68562
Document Number: 110941
The effect of treatment with anti-.beta.2-microglobulin sera on the survival of heart allografts transplanted between 2 isogenous inbred rat strains was studied. Hearts from male Wistar-Furth (WF) rats (Ag-B2) were grafted heterotopically into the peritoneal cavity of male 250-300 g animals of the Brown Norway (BN) strain (Ag-B3). A goat anti-rabbit .beta.2-microglobulin caused a significant but moderate prolongation of the survival of rat heart allografts. The prolongation may be partly attributable to interference with T [thymus-derived] lymphocyte functions.

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