The expression of Bordetella pertussis protective antigens during bacterial multiplication on a medium with a fixed chemical composition
Shmeleva, E.I.; Mertsalova, N.U.; Sukhinova, E.V.; Kirillova, G.A.; Remova, T.N.; Bazhanova, I.G.; Ozeretskovskaia, M.N.; Britsina, M.V.; Ermolova, E.V.; Zakharova, N.S.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2: 47-50
1997
ISSN/ISBN: 0372-9311 PMID: 9245141 Document Number: 473588
The possibility of obtaining native pertussis preparations with high immunobiological activity has been shown. To obtain such preparations, the use of B. pertussis selected strain, its growth under the conditions of static cultivation in a synthetic culture medium and the use of supernatants with the maximum content of protective antigens with the aim of obtaining protective complexes are necessary.