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The structural organization of suspension grafts of human embryonic midbrain in the rat brain

Bystron', I.P.; Otellin, V.A.; Wierzba-Bobrowicz, T.; Dymecki, J.

Tsitologiia 39(7): 560-565

1997

ISSN/ISBN: 0041-3771
PMID: 9490495
Document Number: 473457
Dynamics of survival, differentiation and migration of human fetal cells after their transplantation into the rat brain without immunosuppression was studied using routine histology, electron microscopy and immunocytochemistry. A cell suspension prepared from the ventral mesencephalon of human embryos 7-8 weeks of gestation was injected into the striatum of rats-recipients. The graft development depends on the intensity of immune reaction. Under a weak reaction, the viability and differentiation of human embryo cells in the rat brain were observed within the three months of the experiment. The grafted cells conserve their mediator specificity, some of them being seen to migrate into the host (rat) tissue beyond the graft. In the transplant neuropil various types of cell contacts were observed, including synapses. The described method makes its possible to study the human nervous tissue histogenesis in an abnormal environment.

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Gomot, A.; Gomot, L. 1994: Influence of brain grafts on growth restoration of snail (Helix aspersa) deprived of the midbrain Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 188(2): 153-160
Vasileshnikova, I.P.; Otellin, V.A. 1988: Results of transplanting regions of the midbrain of human embryos into the brain of adult rats Arkhiv Anatomii Gistologii i Embriologii 94(6): 16-20
Otellin, V.A.; Korzhevskiĭ, D.E. 2002: Formation and structural organization of a barrier on the brain outer surface Morfologiia 122(6): 14-18
Asribekova, M.K.; Kalimullina, L.B. 1989: Structural-functional organization of the brain amygdaloid complex in the dynamics of the estrous cycle Biulleten' Eksperimental'noi Biologii i Meditsiny 107(6): 748-750
Kirik, O.V.; Sufiyeva, D.A.; Nazarenkova, A.V.; Korzhevskiy, D.E. 2015: Structural Organization of the Processes of Ependymo- Cytes Lining the Lateral Ventricles of the Rat Brain Morfologiia 147(3): 17-21
Kakabadze, I.M.; Kostenko, N.A. 1990: Structural organization of the fronto-parietal area of the sensory-motor cortex of the rat brain Arkhiv Anatomii Gistologii i Embriologii 98(1): 21-26
Lodin, Z.; Fleischmannová, V.; Hájková, B.; Faltin, J.; Hartman, J. 1981: Reaggregation of human, chick, and human embryonic brain cells. Factors influencing the formation of a histiotypic unit Zeitschrift für Mikroskopisch-Anatomische Forschung 95(5): 701-720
Sukhorukova, E.G.; Alekseeva, O.S.; Kirik, O.V.; Grudinina, N.A.; Korzhevskiĭ, D.E. 2011: Structural organization of superficial glial limiting membrane and layer i astrocytes in rat brain cortex Morfologiia 140(6): 32-35
Kilpatrick, B.A.; Huang, E.S. 1978: Structural organization of human cytomegalovirus DNA Iarc Scientific Publications 1978(24 Part 1): 105-112
Lodin, Z.; Hartman, J.; Lisá, V.; Faltin, J.; Jankásková, B.; Srajer, J. 1987: Correlation between changed biophysical properties of surface membranes and embryonic brain cell adhesivity. Influence of detergents, fixation, EGTA, colchicine, vinblastine, increased K+, ouabain and DMA on the primary cellular adhesivity of embryonic brain cell Physiologia Bohemoslovaca 36(1): 83-88
Korzhevskiĭ, D.E. 2002: Structural organization of choroid plexus primordium in human telencephalon Morfologiia 121(1): 63-67
Varshavskiĭ, A.I.; Levin, V.N. 1981: Structural organization of the microcirculatory bed of the primordia of human deciduous teeth Arkhiv Anatomii Gistologii i Embriologii 80(5): 38-47
Iudintseva, N.M.; Blinova, M.I.; Pinaev, G.P. 2008: Characteristics of cytoskeleton organization of human normal postnatal, scar and embryonic skin fibroblasts spreading on different proteins of extracellular matrix Tsitologiia 50(10): 861-867
Manakova, T.E. 1974: Cultivation of a suspension of embryonic liver of mice in vitro Problemy Gematologii i Perelivaniia Krovi 19(11): 26-31
Simonin, F.; Befort, K.; Gavériaux-Ruff, C.; Matthes, H.; Nappey, V.; Lannes, B.; Micheletti, G.; Kieffer, B. 1994: The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain Molecular Pharmacology 46(6): 1015-1021
Glazkov, M.V. 1988: Structural-functional organization of DNA in the interphase nucleus. Structural aspects Molekuliarnaia Biologiia 22(1): 16-30
Taylor, S.M.; Freemantle, S.J.; Moran, R.G. 1995: Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus Cancer Research 55(24): 6030-6034
Bogolepova, I.N. 2002: Structural bases of individual variability in the human brain Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2002(6): 31-35
Blazek, V.; Brùzek, J.; Casanova, M.F. 2011: Plausible mechanisms for brain structural and size changes in human evolution Collegium Antropologicum 35(3): 949-955
Bogolepova, I.N. 2001: Prerequisites for structural asymmetry of Broca's motor speech area of the human brain Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 4: 61-64