Control of fertility with microdoses of D'norgestrel
Ruiz Velasco, V.; Rodríguez Argüelles, J.; Murguía Peñaloza, R.
Ginecologia y Obstetricia de Mexico 33(199): 441-449
1973
ISSN/ISBN: 0300-9041 PMID: 4714530 Document Number: 473143
113 multiparous fertile women ranging in age from 20 to 40 with regular menstrual cycles and who had not taken orals for 90 days prior to the trial were given continuous daily doses of 37.5 mcg of D-norgestrel for 4-14 cycles for a total of 1163 cycles of observation. A group of 20 who completed 14 cycles of treatment were given extensive physicals before and after the investigation including endometrial biopsies, vaginal hormone cytology, and blood and liver function tests. None of the patients became pregnant. Side effects were minimal and consisted mainly of headaches and nervousness. The most commonly experienced menstrual irregularities were amenorrhea and short cycles. In 2 cases curettage was done because of continuous bleeding. There was no incidence of thrombosis. There were no important changes in blood count, blood chemistry, urine, or in hepatic function. The biopsies indicated that the drug suppressed ovulation.