Mechanisms of cell death in Alzheimer's disease
Luquin, M.R.; Martínez-Vila, E.; Saldise, L.
Revista de Medicina de la Universidad de Navarra 41(1): 34-45
1997
ISSN/ISBN: 0556-6177 PMID: 9527712 Document Number: 470530
Molecular mechanisms involved in neuronal degeneration in Alzheimer's disease remain still unknown. A toxic effect induced by beta amyloid, oxidative stress, excitotoxicity and alterations in signal transduction mechanisms are the main factors linked to neuronal death. In addition, it has been suggested that apoptosis may also participate as a part of the cascade of events resulting in neurodegeneration.
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