Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer's disease
Münch, G.; Gasic-Milenkovic, J.; Arendt, T.
Journal of Neural Transmission. Supplementum 2003(65): 63-71
2003
ISSN/ISBN: 0303-6995 PMID: 12946049 Document Number: 564503
In Alzheimer's disease, neurons in affected regions re-enter the cell cycle, leave the G0 state and appear to be arrested at both the G1/S and G2/M phase with resulting cell death, predominantly by apoptosis. Further hallmarks of AD are crosslinked protein deposits (amyloid plaques and neurofibrillary tangles), which time-dependently become modified by "advanced glycation endproducts (AGEs)". Since AGEs activate both mitogenic and redox-sensitive pathways, they might be involved both in cell cycle re-entry and arrest.