Mechanisms of immune lysis. I. Physiological distinction between target cell death mediated by cytotoxic T lymphocytes and antibody plus complement
Russell, J.H.; Masakowski, V.R.; Dobos, C.B.
Journal of Immunology 124(3): 1100-1105
1980
ISSN/ISBN: 0022-1767 PMID: 6965686 Document Number: 158557
The pattern of progressive release of cytosolic (52Cr) and nuclear (125IUdR) labels from normal or tumor cells being lysed by CTL is strikingly different from the pattern observed when similar cells are lysed by Ab + C or hypotonic shock. We propose that these differences reflect physiologic differences in the lytic events associated with Ab + C- and CTL-mediated cell death.
Document emailed within 1 workday
Related Documents
Ratner, A.; Clark, W.R. 1991: Lack of target cell participation in cytotoxic T lymphocyte-mediated lysis Journal of Immunology 147(1): 55-59Russell, J.H.; Masakowski, V.; Rucinsky, T.; Phillips, G. 1982: Mechanisms of immune lysis. III. Characterization of the nature and kinetics of the cytotoxic T lymphocyte-induced nuclear lesion in the target Journal of Immunology 128(5): 2087-2094
Levy, P.C.; Looney, R.J.; Shen, L.; Graziano, R.F.; Fanger, M.W.; Roberts, N.J.; Ryan, D.H.; Utell, M.J. 1990: Human alveolar macrophage FcR-mediated cytotoxicity. Heteroantibody- versus conventional antibody-mediated target cell lysis Journal of Immunology 144(10): 3693-3700
Kyburz, D.; Speiser, D.E.; Aebischer, T.; Hengartner, H.; Zinkernagel, R.M. 1993: Virus-specific cytotoxic T cell-mediated lysis of lymphocytes in vitro and in vivo Journal of Immunology 150(11): 5051-5058
Lavrovskiĭ, V.A.; Tikhonov, V.I.; Rubtsov, G.B.; Razvoretnev, V.A. 1976: Target cell production of substances modifying the degree of their lysis by immune lymphocytes and macrophages Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 12: 77-81
Alber, D.G.; Greensill, J.; Killington, R.A.; Stokes, A. 1995: Role of T-cells, virus neutralising antibodies and complement-mediated antibody lysis in the immune response against equine herpesvirus type-1 (EHV-1) infection of C3H (H-2k) and BALB/c (H-2d) mice Research in veterinary science 59(3): 205-213
DiSciullo, S.O.; Laux, D.C. 1977: In vitro lysis of tumor cells by antibody and complement: detection of antibody with low cytotoxic reactivity Journal of the National Cancer Institute 59(6): 1631-1636
Kranz, D.M.; Pasternack, M.S.; Eisen, H.N. 1987: Recognition and lysis of target cells by cytotoxic T lymphocytes Federation Proceedings 46(2): 309-312
Ohanian, S.H.; Borsos, T. 1975: Lysis of tumor cells by antibody and complement. II. Lack of correlation between amount of C4 and C3 fixed and cell lysis Journal of Immunology 114(4): 1292-1295
Hoo, W.S.; Kranz, D.M. 1993: Role of CD8 in staphylococcal enterotoxin B-mediated lysis by cytotoxic T lymphocytes Journal of Immunology 150(10): 4331-4337
Russell, J.H. 1986: Phorbol-ester stimulated lysis of weak and nonspecific target cells by cytotoxic T lymphocytes Journal of Immunology 136(1): 23-27
Richieri, G.V.; Kleinfeld, A.M. 1990: Free fatty acids inhibit cytotoxic T lymphocyte-mediated lysis of allogeneic target cells Journal of Immunology 145(4): 1074-1077
Nagler-Anderson, C.; Verret, C.R.; Firmenich, A.A.; Berne, M.; Eisen, H.N. 1988: Resistance of primary CD8+ cytotoxic T lymphocytes to lysis by cytotoxic granules from cloned T cell lines Journal of Immunology 141(10): 3299-3305
Fan, J.; Bonavida, B. 1981: Studies on the induction and expression of T cell-mediated immunity. XII. The concomitant loss and recovery of membrane-associated Lyt-2 antigens, lymphocyte-target cell binding, and the antigen-specific and -nonspecific cytotoxic activity of alloimmune T lymphocytes after treatment with trypsin Journal of Immunology 127(5): 1856-1864
Schaapherder, A.F.; Wolvekamp, M.C.; te Bulte, M.T.; Bouwman, E.; Gooszen, H.G.; Daha, M.R. 1996: Porcine islet cells of Langerhans are destroyed by human complement and not by antibody-dependent cell-mediated mechanisms Transplantation 62(1): 29-33
Nishio, M.; Spielman, J.; Lee, R.K.; Nelson, D.L.; Podack, E.R. 1996: CD80 (B7.1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis Journal of Immunology 157(10): 4347-4353
Bradley, T.P.; Bonavida, B. 1982: Mechanism of cell-mediated cytotoxicity at the single cell level. V. the importance of target cell structure in cytotoxic T lymphocyte-mediated antigen nonspecific lectin-dependent cellular cytotoxicity Journal of Immunology 129(6): 2352-2356
Hiserodt, J.C.; Bonavida, B. 1981: Studies on the induction and expression of T cell-mediated immunity. XI. Inhibition of the "lethal hit" in T cell-mediated cytotoxicity by heterologous rat antiserum made against alloimmune cytotoxic T lymphocytes Journal of Immunology 126(1): 256-262
Doherty, P.C.; Solter, D.; Knowles, B.B. 1977: H-2 gene expression in required for T cell-mediated lysis of virus-infected target cells Nature 266(5600): 361-362
Bradley, T.P.; Bonavida, B. 1982: Mechanism of cell-mediated cytotoxicity at the single cell level. IV. Natural killing and antibody-dependent cellular cytotoxicity can be mediated by the same human effector cell as determined by the two-target conjugate assay Journal of Immunology 129(5): 2260-2265