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HLA-DR:DQ genotypes and insulin-dependent diabetes in Senegal

Cisse, A.; Chauffert, M.; Julier, C.; Chevenne, D.; Michel, S.; Trivin, F.; Diop, S.N.; Sidibe, E.H.; Sow, A.M.

Dakar Medical 41(2): 75-78

1996

ISSN/ISBN: 0049-1101
PMID: 9827098
Document Number: 469386
At the opposite of HLA-DR, HLA-DQ was not well documented in homogeneous negroïd populations. So, 93 IDDM and 115 control patients, all black senegalese people, were studied. The results showed three HLA-DQ IDDM-related susceptibility genotypes and also a high risk conferred by HLA-DR4/DR9 usually described in Mongoloïd people. Furthermore, DR:DQ associations allowed the identification of three IDDM predisposition genotypes, each of them with a characteristic mean age for disease diagnosis.

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