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The expression of nuclear proliferation antigen in oropharyngeal carcinoma

Caminero Cueva, M.J.; Núñez Batalla, F.; Suárez Nieto, C.; Ablanedo Ablanedo, P.

Acta Otorrinolaringologica Espanola 47(5): 377-382

1996

ISSN/ISBN: 0001-6519
PMID: 8991405
Document Number: 467633
Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle. Immunohistochemical detection of the protein is a useful marker of the proliferating cell fraction in tissue specimens. A series of 106 oropharyngeal carcinomas were evaluated using the streptavidin biotin immunoperoxidase method for detection of this protein. PCNA positivity ranged from 9 to 90.2% (mean: 54.86%; SD: 22.05). PCNA results did not correlate with clinical or histological parameters. Cox regression analysis confirmed the absence of statistical significance of the PCNA index in relation to overall survival.

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