Determination of the end-point of naproxen sodium granules in Glatt VG-WS-CD high-shear granulator fluid bed dryer equipment
Jekóné, B.Z.; Görgeyné, K.E.
Acta Pharmaceutica Hungarica 66(6): 247-252
1996
ISSN/ISBN: 0001-6659 PMID: 9604490 Document Number: 467609
Determination of the end-point of granulation in the Glatt VG-600-WS-CD-120 high shear granulator-fluid dryer is presented. The method of the determination based on measuring of the impeller motor current during the granulation operation. The influencing parameters during the granulation of naproxen-sodium on granule-quality are also shown. Reproductibility of the acceptable granule-quality in serial producing is documented.