Regulation of tumor marker gene expression
Sakai, M.; Nakabayashi, H.
Nihon Rinsho. Japanese Journal of Clinical Medicine 54(6): 1560-1567
1996
ISSN/ISBN: 0047-1852 PMID: 8691609 Document Number: 467488
Tumor marker is a group of proteins that specifically expressed in association with carcinogenic processes. Thus, studies of regulation mechanisms of the tumor marker genes are important for understanding the possible alteration of gene expression during neoplastic transformation. In this article, we described the molecular mechanisms of the regulation of two major tumor marker genes, i.e. human alpha-fetoprotein (AFP) gene and rat glutathione transferase P(GST-P) gene. Positive and negative mechanisms of each gene regulations are discussed.