Increased inosine-5'-phosphate dehydrogenase gene expression in solid tumor tissues and tumor cell lines
Collart, F.R.; Chubb, C.B.; Mirkin, B.L.; Huberman, E.
Cancer Research 52(20): 5826-5828
1992
ISSN/ISBN: 0008-5472 PMID: 1356621 Document Number: 401714
Inosine-5'-phosphate (IMP) dehydrogenase, a regulatory enzyme of guanine nucleotide biosynthesis, may play a role in cell proliferation and malignancy. To assess this role we examined IMP dehydrogenase expression in a series of human solid tumor tissues and tumor cells lines in comparison with their normal counterparts. Increased IMP dehydrogenase gene expression was observed in brain tumors relative to normal brain tissue and in sarcoma cells relative to normal fibroblasts. Similarly, in several B- and T-lymphoid leukemia cell lines, elevated levels of IMP dehydrogenase mRNA and cellular enzyme were observed in comparison with the levels in peripheral blood lymphocytes. These results are consistent with an association between increased IMP dehydrogenase expression and either enhanced cell proliferation or malignant transformation.