Double filtration and immunoadsorption plasmapheresis in Guillain-Barré syndrome
Kuwabara, S.; Nakajima, M.; Moroo, I.; Hirayama, K.
Rinsho Shinkeigaku 36(2): 289-292
1996
ISSN/ISBN: 0009-918X PMID: 8752682 Document Number: 466911
We studied the effect of double filtration and immunoadsorption plasmapheresis in Guillain-Barré syndrome retrospectively in 70 patients. Thirty three patients had plasmapheresis, of whom 23 had double filtration and 10 immunoadsorption. The rest of 37 patients consisted of a control group. Clinical disability was evaluated using the functional grading scale by Hughes. In patients having a maximum disability of grade 4 and 5, the double filtration plasmapheresis group showed statistically significant improvement at 3 months after the treatment. There was no significant difference in prognoses between the immunoadsorption plasmapheresis and control groups. In mildly-illed patients having grade 2 and 3, the prognoses were not different between the three groups. In Guillain-Barré syndrome, double filtration plasmapheresis, as well as well-established plasma exchange, had benefit for severely-illed patients.