Tetracycline reduces fluoroquinolones-induced bleaching of Euglena gracilis
Ebringer, L.; Krajcovic, J.; Polónyi, J.; Lahitová, N.; Doupovcová, M.; Dobias, J.
Mutation Research 340(2-3): 141-149
1996
ISSN/ISBN: 0027-5107 PMID: 8692178 Document Number: 466021
Inhibitory activity of tetracycline against ofloxacin- and fleroxacin-induced bleaching of green and etiolized Euglena gracilis was examined. Tetracycline hydrochloride in concentrations of 83-2079 mu-M in the light partially inhibited the bleaching activity of 83 mu-M ofloxacin and of 162 mu-M fleroxacin. In the dark, the TC inhibition of the fluoroquinolones-induced bleaching activity was most obvious, the white colony counts were all decreased. The total inhibition of bleaching was observed in 43 mu-M ofloxacin and 81 mu-M fleroxacin both in light and darkness. Cell growth was not significantly influenced by ofloxacin, fleroxacin and tetracycline in the light or darkness. Inhibition of ofloxacin-induced euglena bleaching by tetracycline was more effective in etiolized cells. TC at 0-416 mu-M did not influence the growth of ofloxacin (2.15 mu-M)-induced Salmonella typhimurium revertants.