Tetracycline-induced esophageal ulcers. Report of two cases
Khera, D.C.; Herschman, B.R.; Sosa, F.
Postgraduate Medicine 68(4): 113 115
1980
ISSN/ISBN: 0032-5481 PMID: 6448409 Document Number: 167758
Delayed passage of irritant drugs like tetracycline hydrochloride can cause esophageal ulceration, especially when the medication is taken with only a sip of water before sleeping or by a patient with stricture or motor abnormality of the esophagus. Certain precautions should be taken when prescribing irritant drugs. Patients should be advised to take sufficient quantities of water with the medication and to avoid taking the capsules at bedtime. These drugs should not be given to patients with esophageal obstruction or motility disorders.