Gonadotropins stimulate the proliferation of human epithelial ovarian cancer cell
Feng, Y.; Zhang, X.; Ge, B.
Zhonghua Fu Chan Ke Za Zhi 31(3): 166-168
1996
ISSN/ISBN: 0529-567X PMID: 8758792 Document Number: 464906
To observe the effect of FSH and LH on the proliferation of human epithelial ovarian cancer cell. Human epithelial ovarian cancer AO cells were incubated with follicle stimulating hormone (FSH) and luteinizing hormone (LH) (2U/L and 2.5U/L respectively). They were detected for proliferation by the use of the immunohistochemical technique and morphology. The positive rate of proliferating cell nuclear antigen expressed in the cancer cell was increased significantly (p < 0.05) indicating its proliferation stimulating effect by FSH. The mitosis of cancer cells was increased by FSH and by LH (35%, 16% respectively). It is suggested that FSH and LH can stimulate the proliferation of epithelial ovarian cancer cell, and they may play an important in the development of epithelial ovarian cancer.