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Early endotoxin tolerance--a preventive concept against infection

Staubach, K.H.; Jonas, S.; Kooistra, A.; Bruch, H.P.

Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 113: 360-363

1996

ISSN/ISBN: 0942-2854
PMID: 9101876
Document Number: 464628
After induction of early-phase endotoxin tolerance in a porcine endotoxin shock model over a period of 3-4 days a highly significant survival-time extension (p < or = 0.0001) was achieved. The protective effect of the unspecific tolerant state led to a significant enhancement of cardiorespiratory parameters during the continuous endotoxin challenge. However, the level of tolerance is relative and can be overcome by increasing the endotoxin challenge dose.

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