Ciliary neurotrophic factor antagonizes gentamicin-induced alterations of electric potentials in auditory pathway in guinea pigs
He, C.; Kang, S.J.; Dou, Y.; Shi, X.J.; Wang, C.H.; Ao, S.Z.; Lu, C.L.
Zhongguo Yao Li Xue Bao 17(6): 493-496
1996
ISSN/ISBN: 0253-9756 PMID: 9863139 Document Number: 463044
AIM: To study the effects of ciliary neurotrophic factor (CNTF) on the expressions of gentamicin ototoxicity in guinea pigs. METHODS: The auditory function of pigmented guinea pigs was examined using auditory brainstem response (ABR), cochlea microphonic potential (CM), and action potential of auditory nerve ( AP ). RESULTS: In animals injected gentamicin ( 80 mg cntdot kg-1 cntdot d-1, im), ABR threshold began to elevate on d 20, and prolongations of ABR wave I, IV and the I - IV interpeak latencies were observed. The animals treated with gentamicin for 30 d displayed lower amplitudes of CM and AP (N1) than the controls. CNTF (0. 44 mg cntdot kg-1 cntdot d-1, sc ) inhibited the gentamicin-induced elevation of ABR thresholds, the prolongation of ABR wave I, IV and the I - IV interpeak latencies, and the decreases in amplitudes of CM and AP ( N1). CONCLUSION: CNTF attenuated the gentamicin-elicited auditory impairment in guinea pigs.