Ras-MAPK signaling pathway activated via brain-derived neurotrophic factor
Sun, X.; Mao, M.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 23(4): 915-918
2006
ISSN/ISBN: 1001-5515 PMID: 17002138 Document Number: 604847
Brain-derived neurotrophic factor (BDNF)is the richest neurophin in brain tissue and may act as an activity-dependent neuronal survival factor. In vitro, BDNF plays an important role in preventing cortical neurons from hypoxia-induced neurotoxicity. It could induce a variety of cellular responses such as cell growth, survival, differentiation, and anti-apoptosis mainly via activating mitogen-activated protein kinase (MAPK) and Ca2+/calmodulin-dependent kinase (CaMK) signaling pathways. And among these multiple signaling pathways there is growing evidence of complicated cross talk.