The structure-function relationship of hereditary dysfibrinogens
Matsuda, M.
International Journal of Hematology 64(3-4): 167-179
1996
ISSN/ISBN: 0925-5710 PMID: 8923778 Document Number: 460811
Fibrinogen is a 340-kDa multi-subunit glycoprotein present in plasma and tissues of all classes of vertebrates. Fibrinogen exerts a variety of physiologically important functions, and most of them. if not all, are assigned to certain structures of fibrin including double-stranded fibrin protofibrils and highly crosslinked fibrin networks. Fibrin formation is indeed a series of highly ordered molecular interactions. The mechanisms underlying these molecular interactions have been extensively studied in the last 40 years. but there still remain many enigmas. In this mini-review, the structure-function relationships of hereditary dysfibrinogens are discussed.