Surgical procedure in children with medullary thyroid gland carcinoma with reference to multiple endocrine neoplasia type II
Schäfer, K.; Senninger, N.; Roth, H.; Buhr, H.J.
Langenbecks Archiv für Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft für Chirurgie. Kongress 113: 202-204
1996
ISSN/ISBN: 0942-2854 PMID: 9101831 Document Number: 458237
Between 1988 and 1995 we treated ten patients aged 7-18 years for familial MTC or MEN II syndrome with a total of 17 operations. Using these surgical procedures, 6/9 patients remained free of tumor after 0-8 years (mean 4.5 years). In conclusion, we recommend thyroidectomy [1] in children younger than 5 years of age and a family history of MEN IIa; [2] in children younger than 3 years of age, presenting the characteristic phenotype of MEN IIb, both with a positive test for mutation of the RET protooncogene [4].