The early response of the blood lymphocytes in mice to phosphacol and its practical significance
Bykova, A.A.; Iushkova, T.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 59(4): 38-39
1996
ISSN/ISBN: 0869-2092 PMID: 9026188 Document Number: 457238
Phosphacol drops applied to the eye of a mouse caused an immediate response of the blood lymphocytes. The number of phosphacol-immune rosette-forming and blast forms of lymphocytes increased. The response is specific since the formation of rosettes is blocked by the excess of phosphacol in vitro and does not occur when rausedyl-sensibilized erythrocytes are used. The formation of blast forms is intensified after small doses of phosphacol (10-9), but not rausedyl, are put into a suspension of blood cells. The technique proposed may be used for determination of phosphorus-containing compounds in the organism and the diagnosis of poisoning with them.