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Significance of polyamines for the early diagnosis of spontaneous hemoblastoses in AKR mice

Voronchikhina, L.D.; Vorozhtsova, S.I.; Minakov, V.N.; Zinov'ev, I.V.; Shkanakina, T.P.

Voprosy Onkologii 34(2): 200-204

1988

ISSN/ISBN: 0507-3758
PMID: 3348011
Document Number: 316987
Polyamines levels were studied in various tissue specimens obtained from high-leukemia AKR mice aged 12 months and less. Organ tissues of leukemic animals revealed increased levels of polyamines and changes in their profile. In symptomatic mice, this was matched by relevant morphologic changes. It is inferred that putrescine is a marker of latent leukemia development.

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