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Methionine-enkephalin augments interleukin-6 production and gene expression

Zhong, F.; Li, X.Y.; Yang, S.L.

Zhongguo Yao Li Xue Bao 16(3): 205-209

1995

ISSN/ISBN: 0253-9756
PMID: 7660811
Document Number: 453782
AIM: To study the effect of methionine-enkephalin (met-enk) on the production and gene expression of interleukin-6 (IL-6) both in vivo and in vitro. METHODS: IL-6 was assayed using its dependent cell line MH60 cntdot BSF2 and measured by MTT spectrophotometry. IL-6 gene expression was proceeded by RNA isolation and hybridization with IL-6 cDNA. RESULTS: Met-enk stimulated IL-6 mRNA expression and increased its stability. Met-enk 0.1 and 1 mg cntdot kg-1 ip for 6 d enhanced serum IL-6 levels. CONCLUSION: An up-regulation of IL-6 by met-enk was mediated through an increase in transcriptional activity and stability of IL-6 mRNA.

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