The effect of coronary angioplasty on superoxide anion generation and lipid peroxidation. Propriety of pharmacological intervention
Kowalski, J.; Pawlicki, L.; Kośmider, M.; Skłodowska, M.; Gromadzińska, J.; Kedziora, J.; Luciak, M.; Błaszczyk, J.
Polish Journal of Pharmacology 47(2): 163-168
1995
ISSN/ISBN: 1230-6002 PMID: 8688889 Document Number: 453672
In patients with unstable angina pectoris, subjected (n = 20) or not subjected (n = 12) to percutaneous transluminal coronary angioplasty (PTCA), baseline superoxide anion (O-2 cntdot -) generation by neutrophils in the coronary sinus blood was significantly higher than that found in the basilic vein blood of control healthy subjects (n = 12). During reperfusion following effective PTCA, neutrophil counts in the coronary sinus blood tended to decrease, an effect accompanied by a significant decrease in the neutrophil O-2 cntdot generation and enhancement of blood plasma lipid peroxidation as reflected by increased malonyldialdehyde concentrations.