Lanthanide or transition metal ions-mediated cleavage of DNA by hydroxamic acid derivative
Hashimoto, S.; Nakamura, Y.
Nucleic Acids Symposium Series 34: 17-18
1995
ISSN/ISBN: 0261-3166 PMID: 8841530 Document Number: 453294
N-[5-(hydroxylaminocarbonyl)pentyl]phenanthridium chloride 1 has been shown to induce cleavage of ColE1 DNA in the presence of transition (ferrous, ferric and vanadyl) or lanthanide(III) (lutetium, thulium and europium) metal ions. The addition of free radical scavengers inhibits the former reaction, but does not the latter case.
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