Effects of Onpi-to (TJ-8117) on mesangial injury induced by anti Thy-1 antibody
Hattori, T.; Shindo, S.; Hisada, T.; Fujitsuka, N.; Hibino, T.; Terazono, Y.; Maruno, M.
Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica 105(2): 63-75
1995
ISSN/ISBN: 0015-5691 PMID: 7737594 Document Number: 453142
We investigated the effect of Onpi-to (TJ-8117) on the mesangial injury induced by anti-Thy-1 antibody. TJ-8117 (400 mg/kg/day, p.o.) given from the 1st day (from the day of injection of the anti-thymocyte serum) or 4th day (after mesangial proliferation), markedly inhibited the mesangial proliferation and hypercellularity in glomeruli. TJ-8117 prevented the increase in the number of PCNA or ED-1 positive cells in glomeruli. These results suggest that TJ-8117 is effective against glomerular disease with mesangial injury.