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Antimicrobial activities of clavulanic acid/ticarcillin against clinical isolates

Koguchi, M.; Suzuki, Y.; Tanaka, S.; Fukayama, S.; Ishihara, R.; Deguchi, K.; Oda, S.; Nakane, Y.; Fukumoto, T.

Japanese Journal of Antibiotics 48(12): 1899-1905

1995

ISSN/ISBN: 0368-2781
PMID: 8587164
Document Number: 451948
In order to investigate antimicrobial activities of clavulanic acid/ticarcillin (CVA/TIPC) against Escherichia coli, Enterobacter spp. and Pseudomonas aeruginosa in 1992 and 1994, beta-lactamase activities were analyzed and minimum inhibitory concentrations (MICs) were determined including those of the control drugs. The results are as follows; 1. Compared to a report in 1980, the MIC distributions of CVA/TIPC against E. coli and P. aeruginosa did not show large differences. We found, however, that CVA/TIPC-resistant strains increased among Enterobacter spp. 2. Almost all of CVA/TIPC-resistant strains of Enterobacter spp. were also resistant to cephems and new quinolones, thus they were multiple drug resistant. 3. CVA/TIPC showed strong antimicrobial activities against penicillinase producing E. coli.

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