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Estrogen receptor status and response to chemotherapy in advanced breast cancer

Kiang, D.T.; Frenning, D.H.; Gay, J.; Goldman, A.I.; Kennedy, B.J.

Cancer 46(12 Suppl): 2814-2817

1980

ISSN/ISBN: 0008-543X
PMID: 7448726
DOI: 10.1002/1097-0142(19801215)46:12+<2814::aid-cncr2820461415>3.0.co;2-d
Document Number: 451021
Tumor estrogen receptor status in women with advanced breast cancer was correlated with clinical response to cytotoxic chemotherapy in a retrospective study. Following an extramural review of the clinical data of 40 patients, 26 responded to chemotherapy (65%). The response rate in 19 receptor-rich tumors was 89% and in 21 receptor-poor tumors, 43% (P < 0.01). The lowest response rate (14%) was observed in seven postmenopausal patients with receptor-poor tumors. Clinical characteristics of patients and variants in chemotherapy programs failed to explain the favorable response of receptor-rich tumors to cytotoxic chemotherapy.

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