A proposed model for the prediction of response to endocrine therapy in breast cancer from the estrogen receptor status of one site and the number of metastatic sites
DeWys, W.D.; Allegra, J.C.; Simon, R.; Lippman, M.B.
Cancer Research 40(7): 2423-2427
1980
ISSN/ISBN: 0008-5472 PMID: 7388801 Document Number: 166052
A mathematical model for the prediction of response to endocrine therapy of breast cancer has been developed based on a clonal concept of metastatic spread. The model includes an expression of the likelihood of response of an estrogen receptor-positive site and an expression of the concordance of receptor assays when multiple sites are assayed. Both of these are raised to a power function based on the number of sites of metastases to yield a predicted response rate. An excellent fit of patients receiving endocrine therapy was observed. This model offers valuable insight into the biology of response to endocrine therapy. The model may be extended and refined through additional analyses.