Varying sensitivity to acyclovir of different years' clinical isolates of herpes simplex virus
Briazhikova, T.S.; Isakov, V.A.; Iurlova, T.I.; Golovanova, A.K.
Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 9: 12-15
1995
ISSN/ISBN: 0869-6047 PMID: 7580404 Document Number: 450615
The population of types I and 2 herpes simplex viruses (HSV) to be studied consisted mainly of Acyclovir-sensitive strains. In some cases Acyclovir-resistant HSV strains were detected. The phenotypic profile of the Acyclovir-resistant strains were shown to have low reproduction rates in tissue cultures. Their antigenic character was similar to that of reference strains. Several phenotypic variants concurrently isolated from the same patient differ in their reproductive properties, antigenic characteristics, and sensitivity to Acyclovir. It is expedient to examine HSV isolates from patients for their sensitivity to chemicals used in clinical practice. This will allow patients with herpes infection to be treated on an individual basis.