Effects of nimodipine, felodipine, and verapamil on isolated human arteries
Yao, M.H.; Dai, Z.X.; Xu, D.Z.; Yang, Z.C.
Zhongguo Yao Li Xue Bao 16(1): 36-38
1995
ISSN/ISBN: 0253-9756 PMID: 7771193 Document Number: 450161
AIM: To evaluate whether there might be some difference in the action modes of nimodipine (Nim) and felodipine (Fel). METHODS: Compare the inhibitory effects of Nim and Fel with that of verapamil (Ver) as a representative of phenylalklamine on norepinephrine (NE)- and CaCl-2-evoked contractions of human arteries. RESULTS: In Ca-2+-free and high K+ depolarized solution, inhibitory effects of Nim, Fel, and Ver were more potent on CaCl-2-induced contractions on isolated human arteries than those on NE-induced contractions. In CaCl-2-induced contraction, the pD-2 values for Nim, Fel, and Ver were 7.5, 7.42, 6.35 on uterine arteries; 7.38, 7.65, 7.20 on mesenteric arteries and 7.87, 9.10, 7.32 on renal arteries, respectively. Ver inhibited 2 components of NE-evoked contraction, while Nim and Fel only inhibited extracellular Ca-2+-dependent contraction. CONCLUSION: The result indicates that Fel has a selective action on human renal arteries.