Effects of pimobendan on isolated human right atria strips and on isolated left atria of the rat
Llobell, F.; Dávalos, R.; Laorden, M.L.
European Journal of Anaesthesiology 11(2): 123-125
1994
ISSN/ISBN: 0265-0215 PMID: 8174532 Document Number: 428770
The present study describes the effects of pimobendan on isolated human right atrial strips and on isolated left atria of the rat. Pimobendan induces a positive inotropic effect both in human and rat preparations. The maximal increase (28 +/- 2.0%) obtained with pimobendan in the strips from human right atria was similar to that obtained in left atria of the rat (31 +/- 1.8%). These observations may have some clinical relevance as pimobendan might prove to be an alternative to catecholamines for inotropic support in patients who undergo general anaesthesia.