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Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription

Vaury, C.; Lainé, R.; Noguiez, P.; de Coppet, P.; Jaulin, C.; Praz, F.; Pompon, D.; Amor-Guéret, M.

Cancer Research 55(23): 5520-5523

1995

ISSN/ISBN: 0008-5472
PMID: 7585625
Document Number: 449991
We investigated the transcriptional regulation of cytochrome P450 1A1 (CYP1A1) gene in human lymphoblastoid B cells and report that a high inducibility of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is associated with glutathione S-transferase M1 (GSTM1) null genotype, whereas the presence of at least one GSTM1 allele is correlated with induction of only low levels of CYP1A1 mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin. These data underline the major importance of the CYP1A1 inducibility phenotype associated with the homozygous GSTM1 null genotype in chemically induced cancers.

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