Pathophysiology of hepatitis C virus infection

Camps, J.; Córdoba, J.; Esteban, J.I.; Camps, J; Córdoba, J; Esteban, J.I

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Pathophysiology of hepatitis C virus infection

Camps, J.; Córdoba, J.; Esteban, J.I.

Pathologie-Biologie 43(8): 691-702

1995

ISSN/ISBN: 0369-8114

PMID: 8745591

Document Number: 449321

Any physiopathological hypothesis of HCV infection must explain at least some of the most characteristic features of this infection, namely: 1) persistent infection in the majority of exposed individuals, associated with a wide spectrum of histological damages and fluctuating biochemical expression; 2) low tendency towards spontaneous recovery; 3) high tendency to progress to cirrhosis, 4) high prevalence of autoimmune phenomenons, 5) very weak or absent immunity to reinfection. A model is given taking into account the nature of the HCV genome, the immune response of the host to the infection and the potential mechanism (s) involved in viral persistence.