Hepatitis D virus infection in patients with chronic hepatitis B virus infection
Chuang, W.L.; Chang, W.Y.; Lu, S.N.; Lin, Z.Y.; Chen, S.C.; Hsieh, M.Y.; Wang, L.Y.; Wu, C.C.; Chang, S.F.; Chow, T.Y.
Gaoxiong Yi Xue Ke Xue Za Zhi 3(2): 121-127
1987
ISSN/ISBN: 0257-5655 PMID: 3482274 Document Number: 288941
To assess the prevalence and influence of HDV infection in patients with chronic HBV infection, 111 pathologically proven chronic HBV infection patients, including 64 chronic hepatitis, 10 liver cirrhosis and 37 hepatocellular carcinoma cases were studied. The prevelance of HDV infection was 7.2% (8/111). The prevalence in male and female of occurrence subjects was 7.1% (7/91) and 7.8% (1/13) respectively. The difference of HDV infection among the different age groups was not significant. The prevalence in HBeAg positive, anti-HBe positive and both HBeAg and anti-HBe negative patients was 5.3% (3/56), 8.3% (4/44) and 14% (1/7), respectively. Three patients with HBV DNA were combined with HDV infection (8.1%, 3/37) and 7.1% (2/28) of HBV DNA negative patients were anti-D positive. None of the HBsAg negative patients was anti-D positive (0/26). Patients with liver cirrhosis had a higher HDV infection rate (30% 3/10), but p values were over 0.05 when compared with chronic hepatitis and hepatoma groups. The prevalence of anti-D in patients with SGPT levels over 10 times was less than in patients with SGPT levels between 5 to 10 times (p=0.034). In patients with anti-D, four (50%) were HBeAg positive, three (60%, 3/5) were HBV DNA positive, three (37.5%) had liver cirrhosis and none was with SGPT level over 10 times of normal. From these data, it could be concluded that: male and female subjects were equally susceptible to HDV: HDV infection did not influence the status of HBV infection; the prevalence in different age groups of adults showed no significant differences; HDV infection might increase liver damage; HDV infection played a less important role in acute exacerbation of chronic HBV infection in southern Taiwan.