Frequency of HPV infection and level of glutathione in serum of women with cervix dysplasia
Kwaśniewska, A.; Tukendorf, A.; Semczuk, M.
Medycyna Doswiadczalna i Mikrobiologia 47(3-4): 213-218
1995
ISSN/ISBN: 0025-8601 PMID: 8833934 Document Number: 449129
We have investigated the effect of HPV infection on the development of cervix dysplasias and GSH level in the plasma of 312 women, ranging from 18 to 34 years (x = 23.2). HPV-DNA was estimated using the Digene Hybride Capture System and GSH by the high performance liqvid chromatography method (HPLC). HPV infectior can be connected with a risk of cervical pathology and cervical cancer. Besides HPV infection the other risk factor is a low level of one of the most important antioxidant-glutathione (GSH). The level of GSH decreased while the concentration of GSSG increased in the plasma of women with HPV infection, cervix dysplasias and cancer. Simultaneous investigation of biochemical and virologic parameters in conjugation with the known cytopathologic and epidemiologic risk variables can show the factors that may inhibit or promote cervical carcinogenesis.