Cervical dysplasia in women with human immunodeficiency virus (HIV) in areas of high prevalence of infection
Koffi, B.; Serdouma, E.; Mbolissa-Nguérékoudou, W.; Ngadjou-Kouchou-Fondjo, M.; Pengoussou-Gbatoumba, V.; Sépou, A.; Grésenguet, G.
Gynecologie Obstetrique and Fertilite 38(10): 576-580
2010
ISSN/ISBN: 1769-6682 PMID: 20869289 DOI: 10.1016/j.gyobfe.2010.08.031Document Number: 578442
To determine the prevalence of cervical squamous intraepithelial lesions among HIV-positive women, compared to that of HIV-negative women and identify the different types of lesions in both groups. Cross-sectional study conducted in 16 months in two facilities and the service of pathological anatomy of Bangui. The sample consisted of 250 HIV-positive women matched to 250 HIV-negative women. The parameters studied were the HIV status, the result of cervical smear screening, the rates of CD4 and the data of the interview. The smears were inflammatory in 54.4% of HIV-negative and 46.4% of HIV-positive. Epidermoid intraepithelial lesions of the cervix were more frequent among HIV-positive women than among HIV-negative women with respectively 34.8% and 16.4% (P<0.0001). The low-grade lesions were more common regardless of HIV status of patients. The median age of onset of the LEI was lower among HIV-positive whatever the grade of the lesion. Koïlocytosis was found in 27.2% of HIV-positive women against 9.2% among HIV-negative (P<0.001). The prevention of infection by HIV and HPV and the monitoring of precancerous lesions would allow to prevent their evolution towards invasive cancer.
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