The effects of food on methotrexate absorption
Hamilton, R.A.; Kremer, J.M.
Journal of Rheumatology 22(4): 630-632
1995
ISSN/ISBN: 0315-162X PMID: 7791153 Document Number: 448266
Objective: To determine the effects of food on methotrexate (MTX) absorption in patients receiving MTX for the treatment of rheumatoid arthritis (RA). Methods: Standard pharmocokinetic variables were determined in patients with RA after their usual maintenance dose of MTX, under fasting conditions and after they ate a standard breakfast. Results: No significant differences in area under the serum concentration versus time curve, maximal MTX concentration after dosing (C-max), time to (C-max), bioavailability, urinary MTX, renal clearance of MTX. or creatinine clearance were observed between the 2 dosing conditions. Conclusion: We observed no significant effect of food on MTX absorption or bioavailability. Patients may consume MTX without regard to meals.