Target dose markers. Exposure indicators for environmental epidemiological studies
Dybing, E.; Alexander, J.
Tidsskrift for den Norske Laegeforening Tidsskrift for Praktisk Medicin Ny Raekke 115(10): 1249-1252
1995
ISSN/ISBN: 0029-2001 PMID: 7754496 Document Number: 447292
It is of major importance to have good characterization of individual exposures in environmental epidemiological studies. Quantification of the dose at the site of action (target dose, biologically effective dose) gives the best correlation with health outcome. Target dose markers are indicators which have recently been applied in environmental epidemiological studies. Especially, measurements of adducts to macromolecules (DNA, protein) have been much used. The authors give an overview over available exposure markers, focusing on studies were target dose markers have been employed. It is important to be aware of the limitations associated with the use of such markers.