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The influence of carbohydrates and polyhydric alcohols on the stability of ceftazidime in aqueous solution

Zajac, M.; Siwek, J.

Acta Poloniae Pharmaceutica 52(2): 87-90

1995

ISSN/ISBN: 0001-6837
PMID: 8984848
Document Number: 445572
The kinetics of degradation of ceftazidime in aqueous solutions containing various carbohydrates (glucose and fructose) or polyhydric alcohols (sorbitol and mannitol) was investigated over the pH range 9.92-10.93 at 35 degrees C. A relationship between the degradation rate and the hydroxy compound concentration was observed at each pH studied, and the rate-accelerating effect of the compounds was directly proportional to the hydroxide ion activity.

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