Top Abstract Purchase Related
Home
>
Node
>
Subnode

Effects of a new oxazolidinone derivative AS-8 on serotonin metabolism in the brains of mouse, rat and chick

Chilmonczyk, Z.

Polish Journal of Pharmacology 47(5): 445-449

1995

ISSN/ISBN: 1230-6002
PMID: 8868138
Document Number: 445071
The effect of 5-morpholinemethyl-3-(4-chlorobenzylideneamino)-2-oxazolidin one (AS-8), a potential antidepressant drug, was tested on 5-hydroxytryptamine (5-HT) metabolism in the brains of rat, mouse and chick. The ip administration of AS-8 (25-500 mg/kg) did not modify the cerebral 5-HT level, but significantly increased the level of 5-hydroxyindoleacetic acid (5-HIAA) the main 5-HT metabolite. In animals receiving pargyline (a MAO-A inhibitor which blocks 5-HT catabolism), AS-8 markedly enhanced 5-HT accumulation in the brains of rats and mice, but not chicks. It is concluded that AS-8 is capable of stimulating of 5-HT synthesis at least in the mammalian brain.

Document emailed within 1 workday
Secure & encrypted payments

Miranda, C.L.; Wang, J.L.; Henderson, M.C.; Nakaue, H.S.; Buhler, D.R. 1984: Effects of chlorobenzenes on hepatic porphyrin and drug metabolism in chick embryo and day-old chick Research Communications in Chemical Pathology and Pharmacology 46(1): 13-24
Hanig, J.P.; Seifter, J. 1973: The effects of parenteral administration of catecholamines, serotonin and histamine on behavior and levels of these amines in the brain of the neonate chick Archives Internationales de Pharmacodynamie et de Therapie 202(1): 38-47
Golovachev, A.F.; Nadal'iak, E.A. 1973: Energy metabolism and free-radical concentration in chick embryo and chick livers Biofizika 18(5): 862-867
Ogasawara, H.; Takahashi, S.; Kudo, T.; Kudo, M.; Ishihara, H.; Matsuki, A. 1993: Effects of sevoflurane anesthesia on serotonin metabolism in rat brain Masui. Japanese Journal of Anesthesiology 42(10): 1412-1417
Akagawa, Y.; Masuda, Y.; Maruyama, A.; Shimizu, T.; Hishikawa, Y. 1999: Effects of repeated selective serotonin reuptake inhibitor paroxetine treatments on mouse forced swimming Methods and Findings in Experimental and Clinical Pharmacology 21(9): 599-601
Popova, N.K.; Kulikov, A.V.; Pak, D.F. 1985: Correlation between the number of serotonin type 2 receptors in the frontal cortex of the mouse brain and the expressivity of serotonin-dependent head twitches Biulleten' Eksperimental'noi Biologii i Meditsiny 100(9): 322-324
Kolaczkowska, M.K. 1973: Properties of interferon from mouse brains Archivum Immunologiae et Therapiae Experimentalis 21(3): 453-459
Kononenko, V.I.; Savits'kiĭ, S.I. 1974: The effect of hyper- and hypothyroidism on serotonin and noradrenaline concentration and monoamine oxidase activity in the nerve endings of the brains of rats Ukrains'kyi Biokhimichnyi Zhurnal 46(2): 152-156
Garyfallides, S.; Kyrtopoulos, S.A.; Sekeris, C.E. 1984: Effects of dimethylnitrosamine on RNA synthesis and metabolism in mouse liver Cancer Research 44(11): 5110-5117
Molina-Holgado, E.; Dewar, K.M.; Descarries, L.; Reader, T.A. 1994: Altered dopamine and serotonin metabolism in the dopamine-denervated and serotonin-hyperinnervated neostriatum of adult rat after neonatal 6-hydroxydopamine Journal of Pharmacology and Experimental Therapeutics 270(2): 713-721
Sutomo, F.X.; Woutersen, R.A.; Van den Hamer, C.J. 1992: Effects of elevated zinc intake on the copper metabolism and the pancreas of the mouse Journal of Trace Elements and Electrolytes in Health and Disease 6(2): 75-80
Borsini, F.; Volterra, G.; Lecci, A.; Evangelista, S.; Mancinelli, A.; Cutrufo, C.; Parlani, M.; Mennini, T.; Barone, D.; Meli, A. 1991: Potential antidepressant activity and enhancement of serotonin uptake of a new dibenzothiadiazepine derivative Arzneimittel-Forschung 41(6): 573-580
Pochatov, I.M.; Raevskiĭ, K.S. 1977: Effect of azabutyrone and its analogs on catecholamine metabolism in the brains of rats Farmakologiia i Toksikologiia 40(1): 5-8
Bracco, M.L.; Ancona, M.; Foppiani, E.; Torre, E. 1988: Levels of serotonin and hydroxyindoleacetic acid at various stages of development of chick embryo, after administration of tranylcypromine Bollettino della Societa Italiana di Biologia Sperimentale 64(5): 441-448
Grabowska, G.; Wiśniewski, J. 1989: Effects of IPO-63, Carbaryl, Foschlor and Reglone on Newcastle disease virus replication in chick embryo and chick embryo cell cultures Medycyna Doswiadczalna i Mikrobiologia 41(1): 47-52
Lubach, D.; Kietzmann, M. 1988: Effects of etretinate in epidermal metabolism and histology after abrasio of superficial layers. Mouse tail assay Arzneimittel-Forschung 38(1): 54-59
Bishop, J.R.; Ellingrod, V.L.; Akroush, M.; Moline, J. 2009: The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives Human Psychopharmacology 24(3): 207-215
Dvorkin, V.I.; Kiselev, G.V. 1972: Metabolism of individual phospholipid fractions in the brains of rats poisoned by phosphoorganic cholinesterase inhibitors Biulleten' Eksperimental'noi Biologii i Meditsiny 73(11): 51-53
Vilkov, G.A.; Minoranskaia, A.P.; Kolmakova, T.S. 1983: Changes in catecholamine metabolism in the brains of rabbits after treatment with anti-brain antibodies and lithium ions Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 83(9): 1395-1398
Izumi, Y.; Usui, T.; Okazaki, T.; Mochizuki, T.; Ishikura, H.; Tashima, M.; Sawada, H.; Uchino, H. 1985: Effects of VP-16 on cell growth and metabolism of nucleic acids in mouse leukemia L-1210 cells and on the activity of DNA polymerase i of E. coli Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 48(6): 1371-1380