Effect of gonadotrophins, testosterone and growth hormone on spermatogenesis in two hypophysectomy patients
Martin-Du Pan, R.C.; Aubert, M.L.; Biondo, M.; Campana, A.
Journal de Gynecologie Obstetrique et Biologie de la Reproduction 24(4): 357-361
1995
ISSN/ISBN: 0368-2315 PMID: 7650310 Document Number: 444809
Human chorionic gonadotrophin (hCG), human menopausal gonadotrophins (hMG) and somatotrope hormone (STH) were used for three months to induce spermatogenesis in a patient with azoospermia following hypophysectomy for Cushing's syndrome. Azoospermia reappeared when testosterone was substituted for hCG, despite continued treatment with FSH and STH. In a second patient who had undergone hypophysectomy for a craniopharyngioma presenting residual oligospermia, STH alone was uneffective in improving the sperm count. In both patients, the level of IGF-1 in seminal fluid was unchanged by STH despite increased serum IGF-1. The use of STH to induce spermatogenesis is discussed in light of its capacity to increase testosterone synthesis is response to hCG.