Role of growth hormone in spermatogenesis in mice
Unnithan, R.R.; Tandon, V.L.
Indian Journal of Experimental Biology 20(10): 734-737
1982
ISSN/ISBN: 0019-5189 PMID: 7160860 Document Number: 185081
Treatment of fertile male mice with rabbit antiserum to bovine growth hormone (0.1 ml/day for 30 days) caused severe testicular damage characterized by a loss of normal tubular pattern, cell necrosis, exfoliation of cells into the tubular lumina and giant cell formation. The process of spermatogenesis was arrested at the early spermatid stage. However, 30 days after the withdrawal of the treatment, spermatogenic activity was resumed and normal tubular pattern was restored. Growth hormone evidently plays some specific role in the process of spermatogenesis in mice, though its mode and site(s) of action is still unknown.