Myasthenia induced by tiopronin in the treatment of rheumatoid arthritis
Bonnet, M.; Angibaud, G.; Cantagrel, A.; Montastruc, J.L.; Clanet, M.
Revue Neurologique (Paris) 151(1): 67-68
1995
ISSN/ISBN: 0035-3787 PMID: 7676135 Document Number: 443846
Myasthenia gravis (MG) is a well known side-effect of D-Penicillamine used in the treatment of rheumatoid polyarthritis. Tiopronin is another drug available in France, which can also induce MG. Drug-induced MG are characterized by frequent involvement of facial and oropharyngeal muscles. Moreover, the generalization is scarce and the outcome always quite good. No thymoma is present, anti-acetylcholine receptors antibodies are often highly positive. Furthermore, some HLA phenotypes are most frequently found among patients with drug-induced MG suggesting a genetic predisposition. This observation underlines the interest of careful management of patients treated by tiopronin.