Tiopronin, an example of hydrosulphonated derivatives used in the treatment of rheumatoid polyarthritis. Study of immunologic effects
Youinou, P.; Delecoeuillerie, G.; Fauquert, P.; Lelong, A.; Dumay, A.; Le Goff, P.
Revue du Rhumatisme et des Maladies Osteo-Articulaires 57(3): 287-291
1990
ISSN/ISBN: 0035-2659 PMID: 1971455 Document Number: 351457
Fifteen patients with rheumatoid arthritis were treated with tiopronine, and an immunological check-up carried out before the onset and after a two-month treatment. The latex test titres decreased, and there was a significant fall in the levels of IgA-containing circulating immune complexes, in parallel with a depletion of plasma complement breakdown products. Patients displayed a decrease in CD8+T cells and in CD4+Leu 8-T cells and a high proportion of activated T lymphocytes. This returned to normal after treatment. Treatment with TP led also to a reduction of adherence and chemotaxis of polymorphonuclear cells.